Nephroprotective Potential of Sphaeranthus indicus Linn Extract against Hyperglycemia and Dyslipidemia in Streptozotocin-Induced Diabetic Nephropathy

Abstract Objective This study was aimed at determining the nephroprotective potential of Sphaeranthus indicus Linn methanol extract (SME) against hyperglycemia and dyslipidemia in streptozotocin (STZ)-induced diabetic nephropathy (DNP) adult Wistar albino rats. Materials Methods Following STZ-induced diabetes, rats either sex with serum glucose level more than 250 mg/dL were chosen randomized into six groups (n = 6 per group) received treatment as follows: Group I: Normal nondiabetic (ND) a single intraperitoneal dose citrate buffer same volume STZ 1% (w/v) carboxymethyl cellulose (CMC) os (po), group II: (STZ) control oral dosage CMC, III, IV V: + SME treated suspension (100, 200, 400 mg/kg, po) VI: MET metformin (500 CMC. From 28th day to 56th injection, given for 28 days form freshly prepared suspension. The impact DNP analyzed through estimation body weight, glucose, hemoglobin A1c levels, renal functional parameters, lipid profile, oxidative stress markers, analysis histoarchitecture. Result Diabetic showed significant alterations histoarchitecture contrast normal ND significantly reduced hyperglycemia-induced enhanced profile stress, normalized restored by reducing vacuolar degeneration tubules These findings attributed SME's efficacy DNP. Conclusion In STZ-sensitized rats, retarded progress nephropathy. observed is ascribed its hypoglycemic, hypolipidemic, antioxidant activities.